Human Angiostatin Kringle 1-3 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB926

R&D Systems, part of Bio-Techne
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MAB926
MAB926-SP
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Mouse

Applications

Validated:

Western Blot

Cited:

ELISA Development

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 79735

View all Angiostatin Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human Angiostatin Kringle 1-3
Val98-Ser358 (Cys88Ser, Cys316Ser)
Accession # P00747

Specificity

Detects human Angiostatin Kringle 1-3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody also detects plasminogen but does not cross-react with recombinant mouse Angiostatin.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human Angiostatin Kringle 1-3 Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human Angiostatin Kringle 1-3

Formulation, Preparation, and Storage

Purification

Protein A or G purified from ascites

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Angiostatin

Plasminogen is the precursor of plasmin, an active serine protease that dissolves the fibrin of blood clots and acts in many other processes such as embryonic development, tissue remodeling, inflammation and tumor invasion. Synthesized in the kidney, plasminogen is found in plasma and many extracellular fluids. Activated by u- or t-plasminogen activator, the single-chain plasminogen is converted to plasmin that consists of a disulfide bond-linked heavy chain A and light chain B. Heavy chain A contains 5 kringle domains and light chain B corresponds to the serine protease domain. A fragment consisting of the first 4 kringle domains has been named angiostatin, a novel angiogenesis inhibitor.

Alternate Names

HAE4

Entrez Gene IDs

5340 (Human); 18815 (Mouse)

Gene Symbol

PLG

UniProt

P00747

Additional Angiostatin Products

Product Documents for Human Angiostatin Kringle 1-3 Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Angiostatin Kringle 1-3 Antibody

For research use only

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