K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human CD98 APC-conjugated Monoclonal Antibody (Catalog # FAB5920A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human CD98 APC-conjugated Antibody

Application

Recommended Usage

Flow Cytometry

10 µL/10⁶ cells
Sample: K562 human chronic myelogenous leukemia cell line

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: CD98

CD98, also known as 4F2hc, is a ubiquitously expressed, 85-95 kDa member of the SLC3 (solute carrier 3) family of amino acid transporters. It is a type II transmembrane glycoprotein that covalently-associates with a variable number of small, 38-45 kDa, 12-transmembrane proteins that belong to the SLC7 family of molecules. The 120-130 kDa heterdimeric 4F2 complex is known to transport neutral or cationic amino acids with, or without, a contribution of sodium. It also interacts with Integrin beta1 and beta3 to promote cell polarization and migration. Notably, CD98 is "vertebrate-restricted," and its appearance evolutionarily has been linked to the onset of tumorigenesis. Over amino acids (aa) 105-529, human and mouse CD98 share 76% aa sequence identity.

Alternate Names

4F2, 4F2hc, CD98, CH98hc, FRP-1, SLC3A2

Entrez Gene IDs

6520 (Human); 17254 (Mouse)

Gene Symbol

SLC3A2

UniProt

P08195

Additional CD98 Products

Product Documents for Human CD98 APC-conjugated Antibody

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Human CD98 APC-conjugated Antibody

For research use only

Citations
Reviews

Spectra Viewer
Flow Cytometry

Human CD98 APC-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB5920A

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

View all CD98 Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Scientific Data Images for Human CD98 APC-conjugated Antibody

Detection of CD98 in K562 Human Cell Line by Flow Cytometry.