Human CNP Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB31271
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Rat IgG2B Clone # 462608
Product Specifications
Immunogen
E. coli-derived recombinant human CNP
Lys24-Cys126
Accession # P23582
Lys24-Cys126
Accession # P23582
Specificity
Detects human pro-CNP and mature CNP53 and CNP29 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) ANP or rhBNP is observed.
Clonality
Monoclonal
Host
Rat
Isotype
IgG2B
Applications for Human CNP Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Human CNP
Sample: Recombinant Human CNP
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CNP
C-Type Natriuretic Peptide (CNP) belongs to the natriuretic peptide family and functions in an autocrine or paracrine fashion. CNP interacts with the GC-B/NPR-B receptor to promote vasorelaxation, vascular remodeling, and the growth and differentiation of bone and neural tissue. CNP is synthesized as a prohormone that is cleaved intracellularly by furin, yielding a 49 aa propeptide and a 53 aa mature peptide (CNP53). Additional cleavage of the mature peptide generates 29 aa and 22 aa peptides (CNP29 and CNP22) which have comparable activity in some assays. Within the 53 aa mature CNP, human shares 96% aa sequence identity with mouse and rat.
Long Name
C-type Natriuretic Peptide
Alternate Names
NPPC
Entrez Gene IDs
4880 (Human)
Gene Symbol
NPPC
UniProt
Additional CNP Products
Product Documents for Human CNP Antibody
Product Specific Notices for Human CNP Antibody
For research use only
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