Human Complement Factor H-related 1/CFHR1 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB4247
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human
Applications
Validated:
Immunoprecipitation, Western Blot
Cited:
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2B Clone # 442127
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 1/CFHR1
Glu19-Ala328
Accession # Q03591
Glu19-Ala328
Accession # Q03591
Specificity
Detects human Complement Factor H-related 1/CFHR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human (rh) CFHR2 or rhCFHR5 is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Applications for Human Complement Factor H-related 1/CFHR1 Antibody
Application
Recommended Usage
Immunoprecipitation
25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Human Complement Factor H‑related 1/CFHR1, see our available Western blot detection antibodies
Sample: Conditioned cell culture medium spiked with Recombinant Human Complement Factor H‑related 1/CFHR1, see our available Western blot detection antibodies
Western Blot
1 µg/mL
Sample: Recombinant Human Complement Factor H-related 1/CFHR1 under non-reducing conditions
Sample: Recombinant Human Complement Factor H-related 1/CFHR1 under non-reducing conditions
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Complement Factor H-related 1/CFHR1
Complement factor H-related protein 1 (CFHR1) is a 43 kDa, secreted member of the factor H family of glycoproteins. It is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human CFHR1 is 312 aa in length. It contains five approximately 60 aa SCRs (short consensus repeats/CCPs/SUSHI repeats) that basically constitute the entire molecule. CFHR1 may play a role in lipoprotein complexes that bind LPS to neutrophils. There is no reported rodent counterpart to CFHR1. Over aa 19‑143 of the CFHR1 precursor, human CFHR2 and CFHR5 show 98% and 86% aa identity, respectively.
Alternate Names
BTA, CFHR1, Complement Factor Hrelated 1, FHR1
Entrez Gene IDs
3078 (Human)
Gene Symbol
CFHR1
UniProt
Additional Complement Factor H-related 1/CFHR1 Products
- All Products for Complement Factor H-related 1/CFHR1
- Complement Factor H-related 1/CFHR1 cDNA Clones
- Complement Factor H-related 1/CFHR1 ELISA Kits
- Complement Factor H-related 1/CFHR1 Lysates
- Complement Factor H-related 1/CFHR1 Primary Antibodies
- Complement Factor H-related 1/CFHR1 Proteins and Enzymes
Product Documents for Human Complement Factor H-related 1/CFHR1 Antibody
Product Specific Notices for Human Complement Factor H-related 1/CFHR1 Antibody
For research use only
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