Human CRELD2  alpha Isoform Antibody

R&D Systems, part of Bio-Techne | Catalog # AF3555

R&D Systems, part of Bio-Techne
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AF3555
AF3555-SP
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

View all CRELD2 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human CRELD2 alpha Isoform
Ala21-Leu353
Accession # AAH50675

Specificity

Detects human CRELD2 alpha isoform in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 30% cross‑reactivity with recombinant mouse (rm) CRELD2 is observed and less than 1% cross-reactivity with recombinant human CRELD1 and rmCRELD1 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human CRELD2  alpha Isoform Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human CRELD2 alpha Isoform

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CRELD2

CRELD2 is an ubiquitously expressed protein that is a second member of the CRELD family of matricellular proteins. Human CRELD2 alpha isoform is synthesized as a 353 amino acid residue precursor protein with a signal peptide, a highly conserved domain rich in glutamic acid and tryptophan (WE), and EGF-like repeats. Multiple isoforms, including the beta isoform with a 27 aa substitution for the C-terminal 96 residues of the alpha isoform, and another isoform with a 32 residue deletion between residues 258 and 289, have been reported. Human CRELD2 has been shown to interact with the alpha4 subunit of the nicotinic acetylcholine receptor and function as a specific regulator of receptor expression. Human CRELD2 shares 76% and 77% amino acid sequence homology with mouse and rat CRELD 2, respectively.

Long Name

Cysteine-rich Protein With EGF-like Domains 2

Alternate Names

cysteine-rich with EGF-like domain protein 2, cysteine-rich with EGF-like domains 2, DKFZp667O055, MGC11256

Entrez Gene IDs

79174 (Human); 76737 (Mouse)

Gene Symbol

CRELD2

UniProt

AAH50675

Additional CRELD2 Products

Product Documents for Human CRELD2  alpha Isoform Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human CRELD2  alpha Isoform Antibody

For research use only

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