Human Fetuin B Biotinylated Antibody

R&D Systems, part of Bio-Techne | Catalog # BAF1725

R&D Systems, part of Bio-Techne
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BAF1725
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AF1725
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Biotin

Antibody Source

Polyclonal Goat IgG

View all Fetuin B Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Fetuin B
Met19-Pro382
Accession # Q9UGM5

Specificity

Detects human Fetuin B in Western blots. In Western blots, less than 2% cross-reactivity with recombinant human (rh) Fetuin A, rhCystatin A, rhCystatin B, rhCystatin C, rhCystatin D, rhCystatin E/M, rhCystatin S, rhCystatin SA, and rhCystatin SN is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human Fetuin B Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human Fetuin B (Catalog # 1725-PI)

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Fetuin B

Fetuins are members of the cystatin superfamily of cysteine protease inhibitors (1‑3). Additional members of this superfamily are kininogen and histidine-rich glycoprotein. Fetuin A and B are two known members of the fetuin family. Hepatocytes are believed to be the principal cellular source, but other cell types also express it (4, 5). Fetuin A, also known as alpha2-Heremans-Schmid glycoprotein, is an inhibitor of basic calcium phosphate precipitation and a negative acute-phase protein (6, 7). Normal circulating levels of Fetuin A in adults (300‑600 ug/mL) fall significantly (30‑50%) during injury and infection (7). Fetuin B is a newer member whose function is not fully characterized (1, 2). Fetuin A and B display similarities and differences in their characteristics. Fetuin B exhibits reduction of calcification, while both mRNA levels were down‑regulated during the acute phase in inflammation-induced rats (4). However, they share only 20% amino acid sequence identity (2). The amounts of Fetuin B in human serum, unlike Fetuin A, vary with gender and are higher in females than in males (4).

References

  1. Oliver, E. et al. (1999) Genomics. 57:352.
  2. Oliver, E. et al. (2000) Biochem. J. 350:589.
  3. Kellemann, J. et al. 1989, J. Biol. Chem. 264:14121.
  4. Denecke, B. et al. (2003) Biochem. J. 376:135.
  5. Schäfer, C. et al. (2003) J. Clin. Invest. 112:357.
  6. Dziegielewska, K. M. et al. (1996) Histochem. Cell Biol. 106:319.
  7. Gangneux, C. et al. (2003) Nucleic Acids Res. 31:5957.

Alternate Names

FETUB

Entrez Gene IDs

26998 (Human)

Gene Symbol

FETUB

UniProt

Q9UGM5

Additional Fetuin B Products

Product Documents for Human Fetuin B Biotinylated Antibody

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Certificate of Analysis

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Product Specific Notices for Human Fetuin B Biotinylated Antibody

For research use only

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