Human FGF-4 Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF235
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Ala31-Leu206
Accession # P08620
Specificity
Clonality
Host
Isotype
Applications for Human FGF-4 Biotinylated Antibody
Immunohistochemistry
Sample: Immersion fixed paraffin-embedded sections of human breast
Western Blot
Sample: Recombinant Human FGF-4 (Catalog # 235-F4)
Human FGF-4 Sandwich Immunoassay
Formulation, Preparation, and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: FGF-4
FGF-4, the product of a developmentally regulated gene (hst-1), is a member of the FGF family that is efficiently secreted. The gene for FGF-4 (also known as FGFK or K-FGF for Kaposi sarcoma-associated FGF) was initially discovered as a transforming gene by the NIH-3T3 focus formation assay using DNA derived from human tumors (including stomach and colon cancers, hepatocellular carcinomas, and Kaposi’s sarcomas). FGF-4 does not seem to be expressed in normal adult tissues. However, expression of the gene is spatially and temporally regulated during embryonic development. The murine homologue of human FGF-4 has been cloned and shown to be 82% homologous to the human protein at the amino acid sequence level. Human FGF-4 has been shown to exhibit cross species activity.
In vitro, FGF-4 is mitogenic for fibroblasts and endothelial cells. FGF-4 has been shown to be a potent angiogenesis promoter in vivo. FGF-4 has potent transforming potential apparently through an autocrine mechanism of action. FGF-4 plays a key role in limb development and has been identified as the molecular mediator of the activities of the apical ectodermal ridge that is required for directing the outgrowth and patterning of vertebrate limbs.
Long Name
Alternate Names
Gene Symbol
UniProt
Additional FGF-4 Products
Product Documents for Human FGF-4 Biotinylated Antibody
Product Specific Notices for Human FGF-4 Biotinylated Antibody
For research use only