Human GLP-1 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB12492

Recombinant Monoclonal Antibody.
R&D Systems, part of Bio-Techne
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MAB12492-100
MAB12492-SP
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Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG2B Clone # 1257C

View all GLP-1 Antibodies »

Product Specifications

Immunogen

Synthetic human GLP-1 peptide
HAEGTFTSDVSSYLEG
Accession # P01275

Specificity

Detects human GLP-1 in sandwich immunoassays.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG2B

Applications for Human GLP-1 Antibody

Application
Recommended Usage

ELISA

This antibody functions as a GLP-1 ELISA detection antibody when paired with Mouse Anti-Human Glucagon Monoclonal Antibody (Catalog # MAB110299).

This product is intended for assay development on various assay platforms requiring antibody pairs.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from cell culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: GLP-1

Glucagon is a preprotein which is cleaved into four distinct peptides, including the hormone GLP-1 (aa 98-128).  GLP-1 is a secreted hormone with multiple effects upon the intestine (gastric motility), pancreas (glucose dependent insulin release) and hypothalamic pituitary axis (modulates LH, THS, CRH, ocytocin and vasopressin secretion). It also affects plasma glucagon levels.  GLP-1 is expressed in enteroendocrine L cells and neurons of the caudal brainstem which project to the forbain, the amygdala and the hypothalamus. Recent studies show pancreatic intra-islet GLP-1 expression, which is regulated by cytokines, hyperglycemia and cell injury.

Long Name

Glucagon-like Peptide 1

Alternate Names

GLP1

Entrez Gene IDs

2641 (Human)

Gene Symbol

GCG

UniProt

P01275

Additional GLP-1 Products

Product Documents for Human GLP-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human GLP-1 Antibody

For research use only

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