Human Integrin beta 7 Alexa Fluor® 488-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB4669G
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Glu20-His723
Accession # P26010
Specificity
Clonality
Host
Isotype
Applications for Human Integrin beta 7 Alexa Fluor® 488-conjugated Antibody
Flow Cytometry
Sample: Human peripheral blood lymphocytes
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: Integrin beta 7
Human Integrin beta7 (also Integrin betaP and M290 IEL Ag) is a 120 kDa member of the Integrin beta chain family of molecules. It is a type I transmembrane glycoprotein that contains a 704 amino acid (aa) extracellular domain (ECD) (aa 20‑723) and a 52 aa cytoplasmic tail. The ECD contains one von Willebrand factor A domain (aa 150‑389) and four cysteine‑rich EGF‑like repeats. One splice variant exists that shows a deletion of aa 501‑648. Integrin beta7 forms a nondisulfide linked heterodimer with alpha4 and alphaE integrins. alpha4 beta7 binds fibronectin, VCAM-1 and MADCAM1, while alphaE beta7 binds E-cadherin. The ECD of human beta7 is 87% aa identical to the ECD of mouse beta7.
Alternate Names
Gene Symbol
UniProt
Additional Integrin beta 7 Products
Product Documents for Human Integrin beta 7 Alexa Fluor® 488-conjugated Antibody
Product Specific Notices for Human Integrin beta 7 Alexa Fluor® 488-conjugated Antibody
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only