Human Latent TGF-beta  bp2/LTBP-2 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB3850

R&D Systems, part of Bio-Techne
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MAB3850
MAB3850-SP
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 327318

View all Latent TGF-beta bp2/LTBP-2 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Latent TGF‑ beta bp2/LTBP‑2
Gln36-Glu1821
Accession # NP_000419

Specificity

Detects human Latent TGF‑ beta bp2/LTBP‑2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse LTMP-4 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human Latent TGF-beta  bp2/LTBP-2 Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human Latent TGF-beta  bp2 under non-reducing conditions only

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Latent TGF-beta bp2/LTBP-2

LTBP-2 is a 240 kDa member of the LTBP and fibrillin families. Unlike other LTBP, LTBP-2 is not a component of the large latent TGF-beta complex. LTBP-2 is a secreted calcium-binding extracellular matrix glycoprotein of elastic tissue 10 nm microfibrils, especially in the lung. The 1786 aa mature human LTBP2 contains 20 EGF‑like domains and four 8-cysteine repeats and shares 80% aa identity with mouse LTBP-2. An RGD sequence and a proline-rich sequence may mediate adhesion of melanoma cells, but for fibroblasts LTBP-2 may actually be an antiadhesion protein. In vivo, proteolysis by plasmin and elastase is likely and may cleave putative adhesion sites.

Alternate Names

Latent TGFbeta bp2, LTBP-2, LTBP2

Entrez Gene IDs

4053 (Human)

Gene Symbol

LTBP2

UniProt

NP_000419

Additional Latent TGF-beta bp2/LTBP-2 Products

Product Documents for Human Latent TGF-beta  bp2/LTBP-2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Latent TGF-beta  bp2/LTBP-2 Antibody

For research use only

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