Human/Mouse/Rat PSMA2 Antibody

PSMA2 (Proteasome subunit alpha type 2; also known as proteasome component C3 and Macropain subunit C3) is an intracellular 25-27 kDa member of the peptidase T1A family of molecules. It is ubiquitously expressed, and participates in the formation of the 700 kDa 20S proteasomal complex. This complex contains four stacked rings, forming a barrel. The top and bottom rings are made of seven alpha-subunits, while the two central rings are composed of seven catalytic beta-subunits. The complex degrades 80-90% of all intracellular proteins through both an ubiquitin-dependent and -independent process. PSMA2 may modulate the activity of select beta-subunits. Human PSMA2 is 234 amino acids (aa) in length. It contains at least five utilized phosphorylation sites plus one nitrated tyrosine. Full-length human PSMA2 shares 99% aa sequence identity with mouse PSMA2.