Human Neurogenin-3 Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF3444
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Biotin
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
E. coli-derived recombinant human Neurogenin-3
Met1-Leu214
Accession # Q9Y4Z2
Met1-Leu214
Accession # Q9Y4Z2
Specificity
Detects human Neurogenin‑3 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human Neurogenin-1 is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human Neurogenin-3 Biotinylated Antibody
Application
Recommended Usage
Western Blot
0.1 µg/mL
Sample: Recombinant Human Neurogenin-3
Sample: Recombinant Human Neurogenin-3
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Neurogenin-3
Neurogenin-3 (NGN3; also Protein atonal homolog 5) is a 23 kDa, developmentally expressed nuclear protein that belongs to a family of atonal-related basic helix‑loop‑helix (bHLH) transcription factors. bHLH proteins typically form dimers when binding to DNA. NGN3 expression is required for the lineage differentiation of all endocrine cell types in the pancreas, including the formation of islet beta cells. NGN3 is also neurogenic, controlling the number of dendrites generated by hippocampal neurons. Human NGN3 is 214 amino acids (aa) in length. It contains a DNA binding region (aa 84‑95) plus an HLH motif (aa 96‑136). Over aa 3‑214, human NGN3 shares 76% and 84% aa identity with mouse and canine NGN3, respectively.
Alternate Names
Atoh5, Math4B, NEUROG3, Neurogenin3, Relax
Gene Symbol
NEUROG3
UniProt
Additional Neurogenin-3 Products
Product Documents for Human Neurogenin-3 Biotinylated Antibody
Product Specific Notices for Human Neurogenin-3 Biotinylated Antibody
For research use only
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