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Human Peptide YY Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB9456

Recombinant Monoclonal Antibody.
R&D Systems, part of Bio-Techne
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MAB9456-100
MAB9456-SP

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2163A

Product Specifications

Immunogen

Human Peptide YY synthetic peptide
Accession # P10082

Specificity

Detects human Peptide YY.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Human Peptide YY Antibody

Peptide YY antibody in Human Pancreas by Immunohistochemistry (IHC-P).

Peptide YY in Human Pancreas.

Peptide YY was detected in immersion fixed paraffin-embedded sections of human pancreas using Rabbit Anti-Human Peptide YY Monoclonal Antibody (Catalog # MAB9456) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rabbit IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC003). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in islet cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Applications for Human Peptide YY Antibody

Application
Recommended Usage

Immunohistochemistry

3-10 µg/mL
Sample: Immersion fixed paraffin-embedded secitons of human pancreas

Formulation, Preparation, and Storage

Purification

Protein A or G purified from cell culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Peptide YY

Peptide YY (PYY), a secretory peptide, is expressed by L cells (enteroendocrine cells) in the small and large intestine, Islet of Langerhans cells, testis, and in some central and peripheral neurons. Because PYY is released from L cells after feeding, it is thought to produce a satiety signal. While the regulation of appetite by PYY and GLP-1 have been studied extensively, recent evidence supports a role for PYY in Islet of Langerhans beta cell survival. PYY secretion is also modulated by gut microbiota, and levels of colonic PYY have reduced in rats with DSS-induced colitis, and in humans with inflammatory bowel disease (IBD), while circulating PYY increased in IBD.

Alternate Names

Peptide-YY, PYY, PYY-I, PYY1

Entrez Gene IDs

5697 (Human); 217212 (Mouse); 287730 (E. faecalis)

Gene Symbol

PYY

UniProt

Additional Peptide YY Products

Product Documents for Human Peptide YY Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Peptide YY Antibody

For research use only

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