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Human Presenilin-1 N-Terminal Fragment Biotinylated Antibody

R&D Systems, part of Bio-Techne | Catalog # BAF149

R&D Systems, part of Bio-Techne
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BAF149

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Biotin

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

E. coli-derived recombinant human Presenilin‑1
Lys1-Lys80
Accession # P49768

Specificity

Detects human Presenilin‑1 N‑Terminal Fragment in Western blots. In Western blots, less than 1% cross‑reactivity with recombinant human Presenilin‑1 C‑Terminal Fragment  (aa 298‑407) and recombinant human Presenilin‑2 C‑Terminal Fragment (aa 1‑80) is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human Presenilin-1 N-Terminal Fragment Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human Presenilin-1 N-Terminal Fragment

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Presenilin-1

Presenilin-1 is a catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). In addition it is required for normal embryonic brain and skeleton development, and for normal angiogenesis.

Alternate Names

Presenilin1, PSEN1, S182

Entrez Gene IDs

5663 (Human)

Gene Symbol

PSEN1

UniProt

Additional Presenilin-1 Products

Product Documents for Human Presenilin-1 N-Terminal Fragment Biotinylated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Presenilin-1 N-Terminal Fragment Biotinylated Antibody

For research use only

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