Human PTH1R/PTHR1 Biotinylated Antibody

R&D Systems, part of Bio-Techne | Catalog # BAF5709

R&D Systems, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Biotin

Antibody Source

Polyclonal Sheep IgG

View all PTH1R/PTHR1 Antibodies »

Product Specifications

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human PTH1R/PTHR1
Tyr23-Met189
Accession # Q03431

Specificity

Detects human PTH1R/PTHR1 in Western blots.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Human PTH1R/PTHR1 Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human PTH1R/PTHR1
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PTH1R/PTHR1

PTH1 R (Parathyroid hormone receptor # 1; also PTH/PTHr receptor) is a predicted 66‑68 kDa member of the G-protein coupled receptor family # 2. It is expressed on a variety of cell types, including hepatocytes, renal epithelium, smooth muscle cells, and osteoblasts plus chondrocytes. PTH1 R is a receptor for both PTH and PTHrP, and PTH binding promotes Ca++-release from bone, mediated by osteoclast formation. Mature human PTH1 R is a 7-transmembrane glycoprotein 567 amino acids (aa) in length. It contains a long, ligand-binding N‑terminal extracellular region (aa 27‑188) and a 130 aa cytoplasmic C-terminal domain. Single aa changes such as Gly121Glu, Ala122Thr and Arg255His can impair PTH1 R signaling. Over aa 1‑189, human PTH1 R shares 88% aa identity with mouse PTH1 R.

Long Name

Parathyroid Hormone Receptor 1

Alternate Names

PTHR, PTHR1

Entrez Gene IDs

5745 (Human); 19228 (Mouse); 56813 (Rat)

Gene Symbol

PTH1R

UniProt

Q03431

Additional PTH1R/PTHR1 Products

Product Documents for Human PTH1R/PTHR1 Biotinylated Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human PTH1R/PTHR1 Biotinylated Antibody

For research use only

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