Human ST6 Gal Sialyltransferase 1/
ST6GAL1 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB5924

R&D Systems, part of Bio-Techne
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MAB5924
MAB5924-SP
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Bacteria - Escherichia coli

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 396012

View all ST6 Gal Sialyltransferase 1/ST6GAL1 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human ST6 Gal Sialytransferase 1/ST6GAL1
Lys27-Cys406
Accession # P15907

Specificity

Detects human ST6 Gal Sialytransferase 1/ST6GAL1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) ST6GAL2, rhST6GALNAC1, or rhST6GALNAC5 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human ST6GAL1 (Catalog # 5924-GT)
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Sterile PBS to a final concentration of 0.5 mg/mL. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ST6 Gal Sialyltransferase 1/ST6GAL1

ST6GAL1 ( beta-galactoside alpha-2-6 sialyl transferase 1; also alpha-2,6-ST) is a 47-49 kDa member of the glycosyltransferase 29 family of proteins. It is principally expressed in hepatocytes, placenta and skeletal muscle, and may be unique in its ability to generate Sia-alpha -2, 6-Gal structures on liver proteins. Human ST6GAL1 is a 406 amino acid (aa) type II transmembrane protein that resides in Golgi membranes. It contains a short cytoplasmic segment (aa 1-9) and an extended luminal domain
(aa 27‑406) that possesses a phosphorylation site at Tyr369. ST6GAL1 undergoes BACE1-mediated cleavage to generate a 364 aa, 52-53 kDa soluble form. This acts within the Golgi lumen to glycosylate proteins destined for secretion. There is one potential alternative start site at Met232. Over aa 27‑406, human ST6GAL1 shares 75% aa identity with mouse ST6GAL1.

Long Name

ST6 beta-Galactoside alpha-2,6-Sialyltransferase 1

Alternate Names

Alpha 2,6-ST, B-cell antigen CD75, CD75, SIAT1, ST6N

Entrez Gene IDs

6480 (Human); 20440 (Mouse); 25197 (Rat)

Gene Symbol

ST6GAL1

UniProt

P15907

Additional ST6 Gal Sialyltransferase 1/ST6GAL1 Products

Product Documents for Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human ST6 Gal Sialyltransferase 1/ST6GAL1 Antibody

For research use only

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