Human TR2/NR2C1 Antibody

Name: Human TR2/NR2C1 Antibody
Brand: R&D Systems
SKU: PP-H0037-00

R&D Systems, part of Bio-Techne | Catalog # PP-H0037-00

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Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human

Applications

Direct ELISA, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG_2B Clone # H0037

View all TR2/NR2C1 Antibodies »

Product Summary for Human TR2/NR2C1 Antibody

Immunogen

Recombinant human TR2/NR2C1
aa 4-110

Specificity

This antibody specifically recognizes human TR2. Not yet tested in other species.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2B

Applications for Human TR2/NR2C1 Antibody

Application

Recommended Usage

Direct ELISA

This antibody can be used at 0.2 μg/mL with the appropriate secondary reagents to detect human TR2.

Immunoprecipitation

Optimal dilutions should be determined by each laboratory.

Western Blot

This antibody can be used at 2 μg/mL under reducing conditions with the appropriate secondary reagents to detect human TR2.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

A liquid formulation in physiologic saline with 0.1% NaN₃.

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Background: TR2/NR2C1

Human Testicular Receptor 2 (TR2, TR2-11; NR2C1) is a 67 - 70 kDa, 603 amino acid member of the NR2 subfamily of the Nuclear Hormone Receptor superfamily. It is expressed in prostate and testis, forms homodimers with itself, and heterodimers with TR4. In addition to TR2-11, there are three other isoforms. All exhibit a DNA binding domain (DBD) (amino acids 111 - 179) and a variable length ligand binding domain (LBD) (amino acids 261 – 603). TR2-7 is truncated at 184 amino acids in length, with amino acids 1 - 181 showing complete identity to TR2-11. There is no LBD. TR2-9 is 467 amino acids in length and is identical to TR2-11 over amino acids 1 – 464. TR2-5 is 483 amino acids in length and identical to TR2-11 over amino acids 1 - 466. Their significance is unclear.

Long Name

Testicular Orphan Nuclear Receptor 2

Alternate Names

NR2C1

Entrez Gene IDs

7181 (Human)

Gene Symbol