Human TR alpha/NR1A1 Antibody

R&D Systems, part of Bio-Techne | Catalog # PP-H2804-00

R&D Systems, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Direct ELISA, Immunohistochemistry, Western Blot

Cited:

Immunocytochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # H2804

View all TR alpha/NR1A1 Antibodies »

Product Specifications

Immunogen

Recombinant human TR alpha/NR1A1
aa 2-51

Specificity

This antibody specifically recognizes human TR alpha and cross-reacts with mouse and rat TR alpha. The antibody does not cross-react with human TR beta. Not yet tested in other species.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human TR alpha/NR1A1 Antibody

Application
Recommended Usage

Direct ELISA

This antibody can be used at 0.1 μg/mL with the appropriate secondary reagents to detect human TR alpha.

Immunohistochemistry

This antibody can be used at 20 - 50 μg/mL with the appropriate secondary reagents to detect human TR alpha.

Western Blot

This antibody can be used at 1 μg/mL under reducing conditions and at 3 μg/mL under non-reducing conditions with the appropriate secondary reagents to detect human TR alpha.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

A liquid formulation in physiologic saline with 0.1% NaN3.

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Background: TR alpha/NR1A1

Thyroid Hormone Receptor alpha (TR alpha, THRA; NR1A1) is a member of the Nuclear Hormone Receptor superfamily. The ligands for TR alpha are the thyroid hormones, which exist in two forms: T4 and T3. TR alpha plays a critical role in the differentiation, growth, metabolism and physiology of a wide variety of tissues. The major partners of TRs are the Retinoid X Receptors (RXRs), which strongly enhance their ability to bind to specific DNA sequences and contribute to the specificity of TR.

Long Name

Thyroid Hormone Receptor alpha

Alternate Names

NR1A1, THRA, v-ErbA1

Entrez Gene IDs

7067 (Human)

Gene Symbol

THRA

Additional TR alpha/NR1A1 Products

Product Documents for Human TR alpha/NR1A1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human TR alpha/NR1A1 Antibody

For research use only

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