Human VGLUT1/SLC17A7 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB9054

R&D Systems, part of Bio-Techne
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MAB9054
MAB9054-SP
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 732607

View all VGLUT1/SLC17A7 Antibodies »

Product Specifications

Immunogen

E.coli-derived recombinant human VGLUT/SLC17A7
Asn93-Thr115
Accession # Q9P2U7

Specificity

Detects human VGLUT/SLC17A7 in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Human VGLUT1/SLC17A7 Antibody

VGLUT1/SLC17A7 antibody in Human Brain by Immunohistochemistry (IHC-P).

VGLUT1/SLC17A7 in Human Brain.

VGLUT1/SLC17A7 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Mouse Anti-Human VGLUT1/SLC17A7 Monoclonal Antibody (Catalog # MAB9054) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to synaptic vesicles. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Applications for Human VGLUT1/SLC17A7 Antibody

Application
Recommended Usage

Immunohistochemistry

8-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human brain (cortex)

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: VGLUT1/SLC17A7

Vesicular glutamate transporter 1 (VGLUT1), also known as SLC17A7, is an integral membrane protein involved in glutamate uptake into synaptic vesicles. The vesicular glutamate transporter (VGLUT) mediates the accumulation of neurotransmitter (glutamate) into synaptic vesicles. It is expressed in pre-synaptic vesicles. VGLUT proteins appear to be differentially expressed in myelinated afferents located in specific axonal populations within the spinal cord. VGLUT proteins are among the most specific markers for the identification of glutamatergic neurons. It is an essential molecular component of glutamate synaptic transmission, and its de-regulation can result synaptic failure and excitotoxicity.

Long Name

Vesicular Glutamate Transporter 1

Alternate Names

BNPI, SLC17A7

Entrez Gene IDs

57030 (Human); 72961 (Mouse); 116638 (Rat)

Gene Symbol

SLC17A7

UniProt

Q9P2U7

Additional VGLUT1/SLC17A7 Products

Product Documents for Human VGLUT1/SLC17A7 Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human VGLUT1/SLC17A7 Antibody

For research use only

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