IFN-alpha/beta R1 Antibody (MM0336-8H64) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-11731

Novus Biologicals, part of Bio-Techne
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NBP2-11731-0.025mg
NBP2-11731
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Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, Flow Cytometry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # MM0336-8H64

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all IFN-alpha/beta R1 Antibodies »

Product Specifications

Immunogen

Human recombinant IFN-alpha/beta R1 (extracellular domain)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for IFN-alpha/beta R1 Antibody (MM0336-8H64) - Azide and BSA Free

Application
Recommended Usage

Flow Cytometry

1:50-1:200

Western Blot

1:500-1:2000
Application Notes
This antibody is Cytof ready.

Formulation, Preparation, and Storage

Purification

Protein G purified

Reconstitution

Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Formulation

Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IFN-alpha/beta R1

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Long Name

Interferon alpha/beta Receptor 1

Alternate Names

IFN-aR1, IFN-bR1, IFNAR1, IFNbR1

Gene Symbol

IFNAR1

UniProt

AAA52730

Additional IFN-alpha/beta R1 Products

Product Documents for IFN-alpha/beta R1 Antibody (MM0336-8H64) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for IFN-alpha/beta R1 Antibody (MM0336-8H64) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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