Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG Clone # 4G7

Format

BSA Free

Concentration

1.0 mg/ml

View all IgE Antibodies »

Product Summary for IgE Antibody (4G7) - BSA Free

Immunogen

Purified human IgE

Specificity

The antibody 4G7 reacts with human IgE; it recognizes an epitope different from the ones recognized by BE5 and 4H10 antibodies to IgE.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for IgE Antibody (4G7) - BSA Free

IgE Antibody (4G7) - BSA Free Flow Cytometry: IgE Antibody (4G7) - BSA Free [NB500-471]

Flow Cytometry: IgE Antibody (4G7) - BSA Free [NB500-471]

Surface staining pattern of human peripheral whole blood stained using anti-human IgE (4G7.325) purified antibody (concentration in sample 0,6 ug/ml, GAM APC).

Applications for IgE Antibody (4G7) - BSA Free

Application
Recommended Usage

ELISA

1:2000

Flow Cytometry

1 - 4 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Multi-step

Formulation

PBS (pH 7.4)

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: IgE

IgE is typically the least abundant isotype - blood serum IgE levels in a normal ("non-atopic") individual are ~150 ng/ml, compared to 10 mg/ml for the IgGs - it is capable of triggering the most powerful immune reactions. Most of our knowledge of IgE has come from research into the mechanism of a form of allergy known as type 1 hypersensitivity. There is much speculation into what physiological benefits IgE contributes, and so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans. IgE may play an important role in the immune system's recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. IgE may be an important target in treatments for allergy and asthma.

Long Name

Immunoglobulin E

Alternate Names

IgE, immunoglobulin heavy constant epsilon

Entrez Gene IDs

3497 (Human)

Gene Symbol

IGHE

Additional IgE Products

Product Documents for IgE Antibody (4G7) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for IgE Antibody (4G7) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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