IGF-I R/IGF1R Antibody (IGF1R/4667)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-13948

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, In vitro assay, Protein Array

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2c Kappa Clone # IGF1R/4667

Concentration

0.2 mg/ml

View all IGF-I R/IGF1R Antibodies »

Product Summary for IGF-I R/IGF1R Antibody (IGF1R/4667)

Immunogen

Recombinant fragment (around aa550-750) of human IGF-I R/IGF1R protein (exact sequence is proprietary) (Uniprot: P08069)

Localization

Cell membrane

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2c Kappa

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP3-14094)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Non-hazardous.

Theoretical molecular weight: 130kDa (IGF-1R); 97kDa (IGF-1R); 200kDa (pro-IGF-1R)

Scientific Data Images for IGF-I R/IGF1R Antibody (IGF1R/4667)

Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948]

Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948]

Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948] - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with IGF-I R/IGF1R antibody (IGF1R/4667).
Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948]

Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948]

Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948] - Formalin-fixed, paraffin-embedded human colon carcinoma stained with IGF-I R/IGF1R antibody (IGF1R/4667).
Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948]

Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948]

Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948] - Formalin-fixed, paraffin-embedded human breast carcinoma stained with IGF-I R/IGF1R antibody (IGF1R/4667).
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Applications for IGF-I R/IGF1R Antibody (IGF1R/4667)

Application
Recommended Usage

Flow Cytometry

1-2 ug/million cells

Immunocytochemistry/ Immunofluorescence

1-4 ug/ml
Application Notes
In-vitro Neutralization of Biological Activity of IGF-1: Order Ab without Azide
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: IGF-I R/IGF1R

The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival

Long Name

Insulin-like Growth Factor I Receptor

Alternate Names

CD221, IGF-1R, IGF-IR, IGF1R, IGFIR

Gene Symbol

IGF1R

UniProt

P08069

Additional IGF-I R/IGF1R Products

Product Documents for IGF-I R/IGF1R Antibody (IGF1R/4667)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IGF-I R/IGF1R Antibody (IGF1R/4667)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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