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IGF-I R/IGF1R Antibody (teprotumumab)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28288

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # teprotumumab

Concentration

LYOPH mg/ml

Product Specifications

Immunogen

IGF1R / CD221

Reactivity Notes

Predicted species reactivity: Mouse

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hulambda. It has a predicted MW of 145.5 kDa.

Also known as 'teprotumumab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for IGF-I R/IGF1R Antibody (teprotumumab)

IGF-I R/IGF1R Antibody (teprotumumab)

ELISA: IGF-I R/IGF1R Antibody (teprotumumab)[NBP3-28288] -

Immobilized human IGF1R His at 2 ug/mL can bind IGF-I R/IGF1R Antibody (teprotumumab), EC50=0.009199 ug/mL.
IGF-I R/IGF1R Antibody (teprotumumab)

Flow Cytometry: IGF-I R/IGF1R Antibody (teprotumumab)[NBP3-28288] -

Human IGF1R CHO-K1 cells were stained with IGF-I R/IGF1R Antibody (teprotumumab) and negative control protein respectively, washed and then followed by APC and analyzed with FACS, EC50=0.1968 nM.

Applications for IGF-I R/IGF1R Antibody (teprotumumab)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: IGF-I R/IGF1R

The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival

Long Name

Insulin-like Growth Factor I Receptor

Alternate Names

CD221, IGF-1R, IGF-IR, IGF1R, IGFIR

Gene Symbol

IGF1R

UniProt

Additional IGF-I R/IGF1R Products

Product Documents for IGF-I R/IGF1R Antibody (teprotumumab)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for IGF-I R/IGF1R Antibody (teprotumumab)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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