IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-81983

Novus Biologicals, part of Bio-Techne
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NB100-81983
NB100-81983-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human

Applications

Validated:

Immunohistochemistry, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all IGF-I R/IGF1R Antibodies »

Product Specifications

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human IGF-I R/IGF1R around the phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-YP-YP-R-K).

Modification

p Tyr1165, p Tyr1166

Specificity

Detects endogenous levels of IGF-I R/IGF1R only when phosphorylated at tyrosine 1165/tyrosine1166.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

Western Blot: IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] -

Western Blot: IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] - Western blot in MCF7 (A), MCF7-insulin-15min (B), A2780 (C) whole cell lysates. (Predicted band size: 154 kD; Observed band size: 95; 200 kD)
IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

Immunohistochemistry-Paraffin: IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] -

Immunohistochemistry-Paraffin: IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody [NB100-81983] - Immunohistochemical staining in human colorectal cancer formalin fixed paraffin embedded tissue section.

Applications for IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

Application
Recommended Usage

Immunohistochemistry

1:50-1:100

Western Blot

1:500-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol

Preservative

0.01% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IGF-I R/IGF1R

There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Long Name

Insulin-like Growth Factor I Receptor

Alternate Names

CD221, IGF-1R, IGF-IR, IGF1R, IGFIR

Entrez Gene IDs

3480 (Human); 16001 (Mouse); 25718 (Rat)

Gene Symbol

IGF1R

UniProt

P08069

Additional IGF-I R/IGF1R Products

Product Documents for IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IGF-I R/IGF1R [p Tyr1165, p Tyr1166] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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