IGFBP-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33475

Novus Biologicals, part of Bio-Techne
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NBP2-33475-25ul
NBP2-33475
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all IGFBP-1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: QQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGS

Reactivity Notes

Reactivity reported in scientific literature (PMID: 24743550).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IGFBP-1 Antibody

Immunohistochemistry-Paraffin: IGFBP-1 Antibody [NBP2-33475]

Immunohistochemistry-Paraffin: IGFBP-1 Antibody [NBP2-33475]

Immunohistochemistry-Paraffin: IGFBP-1 Antibody [NBP2-33475] - Staining in human placenta and skeletal muscle tissues using NBP2-33475 antibody. Corresponding IGFBP1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: IGFBP-1 Antibody [NBP2-33475]

Immunohistochemistry-Paraffin: IGFBP-1 Antibody [NBP2-33475]

Immunohistochemistry-Paraffin: IGFBP-1 Antibody [NBP2-33475] - Staining of human kidney, lymphoid tissues, placenta and skeletal muscle using Anti-IGFBP1 antibody NBP2-33475 (A) shows similar protein distribution across tissues to independent antibody NBP2-33599 (B).
Immunocytochemistry/ Immunofluorescence: IGFBP-1 Antibody [NBP2-33475]

Immunocytochemistry/ Immunofluorescence: IGFBP-1 Antibody [NBP2-33475]

Immunocytochemistry/Immunofluorescence: IGFBP-1 Antibody [NBP2-33475] - Staining of human cell line Hep G2 shows localization to the Golgi apparatus. Antibody staining is shown in green.
View 4 more images

Applications for IGFBP-1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:2500 - 1:5000

Immunohistochemistry-Paraffin

1:2500 - 1:5000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IGFBP-1

IGFBP1 is a gene that codes for an IGF-binding protein that circulates in the plasma and prolongs the half-life of IGFs and works to either inhibit of stimulate the growth promoting effects while also promoting cell migration and has a length of 259 amino acids and a weight of approximately 28 kDa. Current studies are being done on several diseases and disorders relating to this gene including protein-energy malnutrition, pre-eclampsia, persistent fetal circulation syndrome, Silver-Russell syndrome, growth hormone deficiency, Ehlers-Danlos syndrome, glucose intolerance, Prader-Willi syndrome, and chronic fatigue syndrome. IGFBP1 has also been shown to have interactions with IGF1, IGF2, MMP26, TF, and ARNT in pathways such as the myometrial relaxation and contraction, HIF-1-alpha transcription factor, IGF regulation, and protein metabolism pathways.

Long Name

Insulin-like Growth Factor Binding Protein 1

Alternate Names

IGFBP1

Gene Symbol

IGFBP1

UniProt

P08833

Additional IGFBP-1 Products

Product Documents for IGFBP-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IGFBP-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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