IGFBP-rp1/IGFBP-7 Antibody (5A4A9) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-37314

Novus Biologicals, part of Bio-Techne
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NBP2-37314
NBP2-37314-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 5A4A9

Format

BSA Free

Concentration

1 mg/ml

View all IGFBP-rp1/IGFBP-7 Antibodies »

Product Summary for IGFBP-rp1/IGFBP-7 Antibody (5A4A9) - BSA Free

Immunogen

Purified recombinant fragment of human IGFBP-rp1/IGFBP-7 (AA: 52-156) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

29.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for IGFBP-rp1/IGFBP-7 Antibody (5A4A9) - BSA Free

Western Blot: IGFBP-rp1/IGFBP-7 Antibody (5A4A9)BSA Free [NBP2-37314]

Western Blot: IGFBP-rp1/IGFBP-7 Antibody (5A4A9)BSA Free [NBP2-37314]

Western Blot: IGFBP-rp1/IGFBP-7 Antibody (5A4A9) [NBP2-37314] - Western blot analysis using IGFBP7 mAb against HEK293 (1) and IGFBP7 (AA: 52-156)-hIgGFc transfected HEK293 (2) cell lysate.
Western Blot: IGFBP-rp1/IGFBP-7 Antibody (5A4A9)BSA Free [NBP2-37314]

Western Blot: IGFBP-rp1/IGFBP-7 Antibody (5A4A9)BSA Free [NBP2-37314]

Western Blot: IGFBP-rp1/IGFBP-7 Antibody (5A4A9) [NBP2-37314] - Western blot analysis using IGFBP7 mAb against human IGFBP7 recombinant protein. (Expected MW is 36 kDa)
ELISA: IGFBP-rp1/IGFBP-7 Antibody (5A4A9) - BSA Free [NBP2-37314]

ELISA: IGFBP-rp1/IGFBP-7 Antibody (5A4A9) - BSA Free [NBP2-37314]

ELISA: IGFBP-rp1/IGFBP-7 Antibody (5A4A9) [NBP2-37314] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);

Applications for IGFBP-rp1/IGFBP-7 Antibody (5A4A9) - BSA Free

Application
Recommended Usage

ELISA

1:10000

Western Blot

1:500 - 1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IGFBP-rp1/IGFBP-7

Observational study of gene-disease association. (HuGE Navigator. A genome-wide RNA-interference screening to identify genes required for an activated BRAF oncogene to block proliferation of fibroblasts and melanocytes revealed that a IGFBP7, has a central role in BRAF-mediated senescence and apoptosis. This study supports the role of IGFBP-1, -3 and -7 as potential tumour suppressor genes in human breast cancer. IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Expression in tumor cells may reduce the anchorage-independent growth ability, leading to the marked loss of tumorigenicity. discovered the implication of insulin-like growth factor-binding protein-related protein 1 in endometrial physiology, which seems related to endometrial receptivity. data suggest that mac25/IGFBP-rP1 and 25.1 may play a functional role in the NE differentiation of NSCLC cell lines and may provide a novel therapeutic target for treating lung cancers, in particular NSCLC with NE differentiation. findings show for the first time that circulating IGF-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) is increased with insulin resistance. that IGFBP-rP1 is an inhibitor of MCF-7 breast cancer cell proliferation and may act via a cellular senescence-like mechanism. IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1. mRNA expression was lost in six out of eight CRC cell lines as compared to normal colon cells. DNA methylation was found in the region of exon 1 and intron 1 of IGFBP-7. tumor-suppressive activity is through induction of apoptosis in an IGF-I independent manner in prostate cancer. SOX9 contributes to growth regulation by mac25 via inhibition of cell growth and promotion of differentiation. In prostate cancer cells, one of the downstream mediators of the senescence-associated tumor suppression effect of mac25/IGFBP-rP1 is superoxide dismutase 2

Long Name

Insulin-like Growth Factor Binding Protein Related Protein 1

Alternate Names

IGFBP-7, IGFBP7, IGFBPrp1, Mac25, PSF

Gene Symbol

IGFBP7

Additional IGFBP-rp1/IGFBP-7 Products

Product Documents for IGFBP-rp1/IGFBP-7 Antibody (5A4A9) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for IGFBP-rp1/IGFBP-7 Antibody (5A4A9) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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