IGSF4A/SynCAM1/CADM1 Antibody (41N3D3)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-14841

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (98%), Chinese Hamster (98%), Equine (98%), Mouse (98%), Primate (100%), Rabbit (98%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG1 kappa Clone # 41N3D3

Concentration

0.5 mg/ml

View all IGSF4A/SynCAM1 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 150-200 of human CADM1 was used as the immunogen for this antibody.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: 100% homologous in human and primates; mouse (98%), dog (98%), rabbit (98%), horse (98%) and chinese hamster (98%).

Clonality

Monoclonal

Host

Rat

Isotype

IgG1 kappa

Scientific Data Images for IGSF4A/SynCAM1/CADM1 Antibody (41N3D3)

Western Blot: IGSF4A/SynCAM1/CADM1 Antibody (41N3D3) [NBP2-14841]

Western Blot: IGSF4A/SynCAM1/CADM1 Antibody (41N3D3) [NBP2-14841]

Western Blot: SynCAM/CADM1 Antibody (41N3D3) [NBP2-14841] - Analysis of CADM1 recombinant protein using CADM1 antibody at 1 ug/ml. Due to glycosylation, CADM1 can be visualized between 40-80 kD in western blot.

Applications for IGSF4A/SynCAM1/CADM1 Antibody (41N3D3)

Application
Recommended Usage

Western Blot

1-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IGSF4A/SynCAM1

CADM1 (cell adhesion molecule 1) is a protein of an immunoglobulin superfamily. CADM proteins are a diverse group that consist of gtrater than 100 members in vertebrates. These adhesion receptors are involved in cell/cell and cell/matrix interactions. Additionally, CADM proteins are important in differentiation, proliferation, and cell motility. Decreased or loss of function of these molecules can result in disruption to cell adhesion, sometimes resulting in metastasis. CADM1 is a putative tumour suppressor gene which is downregulated in many solid tumours. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC. CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. CADM1 represents a promising biomarker for cancer diagnosis and a potential target for cancer therapy. It has recently been found that downregulation of CADM1 tumor suppressor gene expression is a critical event in neuroblastoma pathogenesis resulting in tumor progression and unfavourable patient outcome.

Long Name

Immunoglobulin Superfamily, Member 4

Alternate Names

BL2, Cadm1, Necl-2, RA175, ST17, SynCAM1, TSLC1

Gene Symbol

CADM1

UniProt

Q9BY67

Additional IGSF4A/SynCAM1 Products

Product Documents for IGSF4A/SynCAM1/CADM1 Antibody (41N3D3)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IGSF4A/SynCAM1/CADM1 Antibody (41N3D3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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