IKB zeta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-57948

Novus Biologicals, part of Bio-Techne
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NBP2-57948
NBP2-57948-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all IKB zeta Antibodies »

Product Summary for IKB zeta Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: CQPFQVRGSQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPM

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IKB zeta Antibody

Immunocytochemistry/ Immunofluorescence: IKB zeta Antibody [NBP2-57948]

Immunocytochemistry/ Immunofluorescence: IKB zeta Antibody [NBP2-57948]

Immunocytochemistry/Immunofluorescence: IKB zeta Antibody [NBP2-57948] - Staining of human cell line RT4 shows localization to nuclear speckles & cytoplasmic bodies.

Applications for IKB zeta Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IKB zeta

IkappaBzeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.

Alternate Names

FLJ30225, FLJ34463, IkappaBzeta, I-kappa-B-zeta, IkappaB-zeta, ikbzeta, IkB-zeta, IL-1 inducible nuclear ankyrin-repeat protein, INAPIkappa B-zeta variant 3, MAILIKBZikB-zeta, Molecule possessing ankyrin repeats induced by lipopolysaccharide, NF-kappa-B inhibitor zeta, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

Gene Symbol

NFKBIZ

Additional IKB zeta Products

Product Documents for IKB zeta Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for IKB zeta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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