IL-11R alpha Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-62351

Novus Biologicals, part of Bio-Techne
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NBP1-62351
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all IL-11 R alpha Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to IL11RA(interleukin 11 receptor, alpha) The peptide sequence was selected from the middle region of IL11RA. Peptide sequence FLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDA. The peptide sequence for this immunogen was taken from within the described region.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 28186993).

Specificity

This product is specific to Subunit or Isoform: alpha.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

43 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for IL-11R alpha Antibody

Western Blot: IL-11R alpha Antibody [NBP1-62351]

Western Blot: IL-11R alpha Antibody [NBP1-62351]

Western Blot: IL11RA Antibody [NBP1-62351] - Human Muscle lysate, concentration 0.2-1 ug/ml.
Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP1-62351]

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP1-62351]

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP1-62351] - The effect of anti-human IL11Ralpha antibody combination treatment with doxorubicin on AN3CA xenograft tumour morphology in vivo. Representative photomicrographs of hematoxylin and eosin stained AN3CA subcutaneous tumour sections are shown in the top panel, arrows denote areas of tissue necrosis. AN3CA subcutaneous tumour sections were immunostained for pSTAT3, cleaved-caspase-3 (apoptosis marker) and Ki-67 (proliferation marker). Bars represent 100 um (H&E), 50 um (pSTAT3) and 200 um (caspase-3, Ki-67). Insets are negative controls. Image collected and cropped by CiteAb from the following publication (https://www.oncotarget.com/fulltext/15187) licensed under a CC-BY license.

Applications for IL-11R alpha Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml
Application Notes
Use in Immunohistochemistry paraffin reported in scientific literature (PMID 28186993).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-11 R alpha

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. IL11RA is the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain.Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.

Long Name

Interleukin 11 Receptor alpha

Alternate Names

IL-11Ra, IL11R alpha, IL11RA

Entrez Gene IDs

3590 (Human)

Gene Symbol

IL11RA

UniProt

Q14626

Additional IL-11 R alpha Products

Product Documents for IL-11R alpha Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for IL-11R alpha Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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