IL-11R alpha Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-31997

Novus Biologicals, part of Bio-Techne
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NBP2-31997
NBP2-31997-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all IL-11 R alpha Antibodies »

Product Summary for IL-11R alpha Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: VESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRL

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (83%), Rat (80%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IL-11R alpha Antibody

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997]

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997]

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997] - Staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997]

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997]

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997] - Staining of human Fallopian tube shows weak to moderate cytoplasmic and membranous positivity in glandular cells.
Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997]

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997]

Immunohistochemistry-Paraffin: IL-11R alpha Antibody [NBP2-31997] - Staining of human pancreas shows very weak positivity in exocrine glandular cells as expected.
View 1 more images

Applications for IL-11R alpha Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-11 R alpha

IL-11 Ra (Interleukin-11 receptor alpha) is a widely expressed transmembrane protein that associates with gp130 to form a functional receptor complex for the cytokine IL-11. gp130 also functions as a subunit in the receptors for Cardiotrophin-1, CNTF, IL-6, IL-27, IL-31, LIF, and Oncostatin M. IL-11 Ra plays a role in female reproduction and the survival of oligodendrocytes and colonic epithelial cells. It enhances osteoclast differentiation and bone remodeling but inhibits adipocyte differentiation. Soluble IL-11 Ra confers IL-11 responsiveness to cells expressing gp130, while in cells expressing transmembrane IL-11 Ra and gp130, soluble IL-11 Ra acts as an IL-11 antagonist.

Long Name

Interleukin 11 Receptor alpha

Alternate Names

IL-11Ra, IL11R alpha, IL11RA

Gene Symbol

IL11RA

UniProt

Q14626

Additional IL-11 R alpha Products

Product Documents for IL-11R alpha Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-11R alpha Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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