IL-12 p70/IL-12A Antibody (OTI2A8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-46050

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI2A8

Concentration

1 mg/ml

View all IL-12 p70 Antibodies »

Product Summary for IL-12 p70/IL-12A Antibody (OTI2A8)

Immunogen

Human recombinant protein fragment corresponding to amino acids 57-253 of human IL12A(NP_000873) produced in E.coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for IL-12 p70/IL-12A Antibody (OTI2A8)

Western Blot: IL-12 p70/IL-12A Antibody (OTI2A8) [NBP2-46050]

Western Blot: IL-12 p70/IL-12A Antibody (OTI2A8) [NBP2-46050]

Western Blot: IL-12 p70/IL-12A Antibody (2A8) [NBP2-46050] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL-12 p70.
Immunohistochemistry: IL-12 p70/IL-12A Antibody (OTI2A8) [NBP2-46050]

Immunohistochemistry: IL-12 p70/IL-12A Antibody (OTI2A8) [NBP2-46050]

Immunohistochemistry: IL-12 p70/IL-12A Antibody (2A8) [NBP2-46050] - Analysis of Carcinoma of Human lung tissue. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0)

Applications for IL-12 p70/IL-12A Antibody (OTI2A8)

Application
Recommended Usage

Immunohistochemistry

1:150

Western Blot

1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IL-12 p70

Interleukin-12, or IL-12, also known as natural killer cell stimulatory factor (NKSF) and cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine that affects both natural killer (NK) cells and T lymphocytes. IL-12 is a heterodimer of subunit IL-12A p35 and subunit IL-12B p40 that is secreted by a wide variety of antigen presenting cells (APCs), including phagocytes, B cells and Langerhans cells. It is involved in mediating many aspects of antiviral immunity. In addition to stimulating T helper cell development, IL-12 is a potent inducer of interferon-gamma (IFN-gamma) production by T cells and NK cells. Increased IL-12 production is a consequence of EBV, CMV, LCMV or HSV infection. While it is unclear what separate effects can be attributed to each IL-12 subunit, evidence suggests IL-12A p35 is the biologically active component responsible for signal transduction via the IL-12 receptor.

Long Name

Interleukin 12 p70

Alternate Names

IL12 p70

Gene Symbol

IL12A

Additional IL-12 p70 Products

Product Documents for IL-12 p70/IL-12A Antibody (OTI2A8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-12 p70/IL-12A Antibody (OTI2A8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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