Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 49M4D2

Format

Azide Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all IL-17RA/IL-17R Antibodies »

Product Specifications

Immunogen

Within the range of amino acids 186-267 of human IL-17RA were used as the immunogen for the antibody.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for IL-17RA/IL-17R Antibody (49M4D2) - Azide Free

Western Blot: IL-17RA/IL-17R Antibody (49M4D2)Azide Free [NBP2-25271]

Western Blot: IL-17RA/IL-17R Antibody (49M4D2)Azide Free [NBP2-25271]

Western Blot: IL-17 RA/IL-17 R Antibody (49M4D2) - Azide Free [NBP2-25271] - Analysis of an IL-17RA recombinant protein fragment and human heart lysate using IL-17RA antibody at 0.5 and 3 ug/ml, respectively. goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: IL-17RA/IL-17R Antibody (49M4D2) - Azide Free [NBP2-25271]

Immunohistochemistry-Paraffin: IL-17RA/IL-17R Antibody (49M4D2) - Azide Free [NBP2-25271]

Immunohistochemistry-Paraffin: IL-17 RA/IL-17 R Antibody (49M4D2) - Azide Free [NBP2-25271] - Formalin-fixed, paraffin-embedded human spleen stained with IL-17RA antibody (1 ug/ml), peroxidase-conjugate and DAB chromogen. TMA was used for this test.

Applications for IL-17RA/IL-17R Antibody (49M4D2) - Azide Free

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1-2 ug/ml

Western Blot

1-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 ml sterile PBS

Format

Azide Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-17RA/IL-17R

IL-17RA (IL-17 receptor A), a type I transmembrane protein with a ubiquitous cell and tissue distribution has no homology with any known cytokine receptor family. This receptor is a member of the IL-17 Receptor family. IL-17RA encodes an unusually large cytoplasmic tail and was shown to activate inflammatory events typical of innate cytokines such as http://imgenex.com/search_result.php?txtSearch=TNFa>TNFa and http://imgenex.com/search_result.php?txtSearch=IL-1b>IL-1b including activation of the transcription factor http://imgenex.com/NF-kBPathway.php>NF-KappaB. IL-17RA is highly expressed on hematopoietic cells, but also at lower levels on osteoblasts, fibroblasts, endothelial cells, and epithelial cells (Chang SH, 2011) (Zhu S, 2010).>The role of the http://imgenex.com/search_result.php?txtSearch=il-17>IL-17 family during parasite infections is an emerging area of research with often contradicting results. In this regard, IL-17RA signaling has been shown to be both deleterious and protective during Toxoplasma gondii infection. Furthermore, two groups demonstrated that IL-17 plays a protective role in T. cruzi infection although the underlying mechanisms remains poorly understood. Indeed, both reports showed significant contradictions that might be related to the different experimental settings but deserves further investigation and discussion, since members of the IL-17 family, http://imgenex.com/search_result.php?txtSearch=il-17a>IL-17A, http://imgenex.com/search_result.php?txtSearch=il-17e>IL-17E and http://imgenex.com/search_result.php?txtSearch=il-17f>IL-17F, are produced during T. cruzi infection. Furthermore, it is confirmed that IL-17RA signaling is required for host resistance during the T. cruzi infection and focused at the mechanisms underlying IL-17RA-mediated protective effect. IL-17RA antibody has the potential to be a therapeutic option for many diseases (Raychaudhuri SP, 2012) (Tosello Boari J .2012).

Long Name

Interleukin 17 Receptor

Alternate Names

CD217, Cdw217, IL-17 R, IL-17 RA, IL17RA

Gene Symbol

IL17RA

Additional IL-17RA/IL-17R Products

Product Documents for IL-17RA/IL-17R Antibody (49M4D2) - Azide Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-17RA/IL-17R Antibody (49M4D2) - Azide Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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