IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-45408

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # OTI2B1

Concentration

1 mg/ml

View all IL-1ra/IL-1F3 Antibodies »

Product Specifications

Immunogen

Full length human recombinant protein of human IL1RN (NP_776215) produced in E.coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1)

Western Blot: IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1) [NBP2-45408]

Western Blot: IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1) [NBP2-45408]

Western Blot: IL-1ra/IL-1F3/IL1RN Antibody (2B1) [NBP2-45408] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1RN.
Immunohistochemistry: IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1) [NBP2-45408]

Immunohistochemistry: IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1) [NBP2-45408]

Immunohistochemistry: IL-1ra/IL-1F3/IL1RN Antibody (2B1) [NBP2-45408] - Analysis of Human tonsil tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min)
Immunohistochemistry: IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1) [NBP2-45408]

Immunohistochemistry: IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1) [NBP2-45408]

Immunohistochemistry: IL-1ra/IL-1F3/IL1RN Antibody (2B1) [NBP2-45408] - Analysis of Human breast tissue. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min)
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Applications for IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1)

Application
Recommended Usage

Immunohistochemistry

1:150

Immunohistochemistry-Paraffin

1:150

Western Blot

1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IL-1ra/IL-1F3

IL-1ra (IL-1 receptor antagonist) is a widely expressed acute phase protein that serves to dampen inflammation. IL-1ra binds to both IL-1 RI and IL-1 RII. It competitively inhibits IL-1 (alpha or beta) binding to IL-1 RI and does not trigger recruitment of the accessory molecule IL-1 R AcP or activation of IL-1 RI signaling. IL-1ra blocks the proinflammatory actions of IL-1 including Prostaglandin E2 and IL-6 release from endothelial cells, fever generation, thrombocytosis, the production of hepatic acute phase proteins, and neutrophil expansion and infiltration.

Long Name

Interleukin 1 Receptor Antagonist

Alternate Names

DIRA, ICIL-1ra, IL-1F3, IL-1ra3, IL-1RN, IL1ra, IL1RN, MVCD4

Gene Symbol

IL1RN

Additional IL-1ra/IL-1F3 Products

Product Documents for IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-1ra/IL-1F3/IL1RN Antibody (OTI2B1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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