IL-1ra/IL-1F3/IL1RN Antibody (SR1317)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21689

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21689-100ul
NBP3-21689-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1317

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all IL-1ra/IL-1F3 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human IL-1ra/IL-1F3/IL1RN (Uniprot #: P18510)

Specificity

Detects endogenous levels of IL-1ra/IL-1F3/IL1RN

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

20 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for IL-1ra/IL-1F3/IL1RN Antibody (SR1317)

Western Blot: IL-1ra/IL-1F3/IL1RN Antibody (SR1317) [NBP3-21689] -

Western Blot: IL-1ra/IL-1F3/IL1RN Antibody (SR1317) [NBP3-21689] - Western blot analysis using NBP3-21689 in (1) HeLa cell lysate; (2) 3T3 cell lysate.

Applications for IL-1ra/IL-1F3/IL1RN Antibody (SR1317)

Application
Recommended Usage

Flow Cytometry

1:50

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:5000-1:20000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-1ra/IL-1F3

IL-1ra (IL-1 receptor antagonist) is a widely expressed acute phase protein that serves to dampen inflammation. IL-1ra binds to both IL-1 RI and IL-1 RII. It competitively inhibits IL-1 (alpha or beta) binding to IL-1 RI and does not trigger recruitment of the accessory molecule IL-1 R AcP or activation of IL-1 RI signaling. IL-1ra blocks the proinflammatory actions of IL-1 including Prostaglandin E2 and IL-6 release from endothelial cells, fever generation, thrombocytosis, the production of hepatic acute phase proteins, and neutrophil expansion and infiltration.

Long Name

Interleukin 1 Receptor Antagonist

Alternate Names

DIRA, ICIL-1ra, IL-1F3, IL-1ra3, IL-1RN, IL1ra, IL1RN, MVCD4

Gene Symbol

IL1RN

Additional IL-1ra/IL-1F3 Products

Product Documents for IL-1ra/IL-1F3/IL1RN Antibody (SR1317)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-1ra/IL-1F3/IL1RN Antibody (SR1317)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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