IL-1ra/IL-1F3/IL1RN Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-81616

Novus Biologicals, part of Bio-Techne
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NBP1-81616
NBP1-81616-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all IL-1ra/IL-1F3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: ETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IL-1ra/IL-1F3/IL1RN Antibody

Immunohistochemistry-Paraffin: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616]

Immunohistochemistry-Paraffin: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616]

Immunohistochemistry-Paraffin: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616] - Analysis in human esophagus and colon tissues. Corresponding IL1RN RNA-seq data are presented for the same tissues.
Western Blot: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616]

Western Blot: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616]

Western Blot: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616] - Analysis in human cell line RT-4.
Immunohistochemistry-Paraffin: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616]

Immunohistochemistry-Paraffin: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616]

Immunohistochemistry-Paraffin: IL-1ra/IL-1F3/IL1RN Antibody [NBP1-81616] - Staining of human skin shows weak to moderate positivity in squamous epithelial cells.
View 4 more images

Applications for IL-1ra/IL-1F3/IL1RN Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-1ra/IL-1F3

IL-1ra (IL-1 receptor antagonist) is a widely expressed acute phase protein that serves to dampen inflammation. IL-1ra binds to both IL-1 RI and IL-1 RII. It competitively inhibits IL-1 (alpha or beta) binding to IL-1 RI and does not trigger recruitment of the accessory molecule IL-1 R AcP or activation of IL-1 RI signaling. IL-1ra blocks the proinflammatory actions of IL-1 including Prostaglandin E2 and IL-6 release from endothelial cells, fever generation, thrombocytosis, the production of hepatic acute phase proteins, and neutrophil expansion and infiltration.

Long Name

Interleukin 1 Receptor Antagonist

Alternate Names

DIRA, ICIL-1ra, IL-1F3, IL-1ra3, IL-1RN, IL1ra, IL1RN, MVCD4

Gene Symbol

IL1RN

Additional IL-1ra/IL-1F3 Products

Product Documents for IL-1ra/IL-1F3/IL1RN Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-1ra/IL-1F3/IL1RN Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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