The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-lamda. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ralpha and IL-20Rbeta. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ralpha and IL-20Rbeta all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

Long Name

Interleukin 20

Alternate Names

IL20

Gene Symbol

IL20

Additional IL-20 Products

Product Documents for IL-20 Antibody (fletikumab) [Allophycocyanin]

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Product Specific Notices for IL-20 Antibody (fletikumab) [Allophycocyanin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IL-20 Antibody (fletikumab) [Allophycocyanin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28331APC

Key Product Details

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Immunogen

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Applications for IL-20 Antibody (fletikumab) [Allophycocyanin]

ELISA

Flow Cytometry

Functional

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Background: IL-20