IL-22 Antibody (8F6F10)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27322

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 8F6F10

Concentration

0.5 mg/ml

View all IL-22 Antibodies »

Product Specifications

Immunogen

Full-length recombinant human IL-22 protein was used as immunogen for this antibody.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for IL-22 Antibody (8F6F10)

Western Blot: IL-22 Antibody (8F6F10) [NBP2-27322]

Western Blot: IL-22 Antibody (8F6F10) [NBP2-27322]

Western Blot: IL-22 Antibody (8F6F10) [NBP2-27322] - Analysis of IL-22 in recombinant protein using IL-22 antibody at 2 ug/mL.

Applications for IL-22 Antibody (8F6F10)

Application
Recommended Usage

Western Blot

0.5 - 2 ug/mL

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS, 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-22

IL-22 is an inflammatory cytokine produced by so-called Th22 cells, especially, as well as Th17 cells. Activating through STAT3 signaling cascades, IL-22 is also expressed by numerous types of lymphocytes including LTi and LTi-like cells in the gut, Nk and T cells, and Langerhans cells which are APCs in the skin (1, 2). The protein is therefore expressed in effector cells of both the Innate and Adaptive Immune systems. Th22 cells, a subset of CD4 cells, preferentially express IL-22 and also express CCR6, CCR4 and CCR10--the latter two representing skin-homing receptors (3-5). Th22 cells do not express RORt or T-bet IL-17A or IFN (4). However, AHR appears to be a key priming transcription element for IL-22 as for IL-17A expression (5). IL-6 and TNF induce Th22 priming (1, 5). It also appears to have positive activities in wound healing and tissue repair since deficiencies in IL-22 in mouse models delay healing of intestinal biopsies (6). Other tissue repair activities have also been identified with the protein. Taken together, IL-22 is thought to be a key to maintaining a balance between inflammation and tolerance, or homeostasis, especially in skin and mucosal organs like the gut.

Long Name

Interleukin 22

Alternate Names

IL-TIF, IL22

Gene Symbol

IL22

UniProt

Q9GZX6

Additional IL-22 Products

Product Documents for IL-22 Antibody (8F6F10)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IL-22 Antibody (8F6F10)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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