IL-7R alpha/CD127 Antibody (R34-34)

Novus Biologicals, part of Bio-Techne | Catalog # DDX0700P-100

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Canine

Applications

Block/Neutralize, Flow Cytometry, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # R34-34

Concentration

0.5 mg/ml

View all IL-7R alpha/CD127 Antibodies »

Product Specifications

Immunogen

IL7R Alpha/CD127 was used as immunogen.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for IL-7R alpha/CD127 Antibody (R34-34)

Flow Cytometry: IL-7R alpha/CD127 Antibody (R34-34) [DDX0700P-100]

Flow Cytometry: IL-7R alpha/CD127 Antibody (R34-34) [DDX0700P-100]

Flow Cytometry: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - Facs staining of PBL with R34-34
Flow Cytometry: IL-7R alpha/CD127 Antibody (R34-34) [DDX0700P-100]

Flow Cytometry: IL-7R alpha/CD127 Antibody (R34-34) [DDX0700P-100]

Flow Cytometry: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - Facs staining of R34-34-transfected Cos7 cells
Immunoprecipitation: IL-7R alpha/CD127 Antibody (R34-34) [DDX0700P-100]

Immunoprecipitation: IL-7R alpha/CD127 Antibody (R34-34) [DDX0700P-100]

Immunoprecipitation: IL-7 R alpha/CD127 Antibody (R34-34) [DDX0700P-100] - R34-34 antigen from 125I-surface labelled Pre-Alp cells

Applications for IL-7R alpha/CD127 Antibody (R34-34)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunoprecipitation

1:10-1:500
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

Tris-NaCl (pH 8.0)

Preservative

No Preservative

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IL-7R alpha/CD127

Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.

Long Name

Interleukin 7 Receptor alpha

Alternate Names

CD127, IL-7 R alpha, IL-7Ra, IL7R, IL7R alpha

Gene Symbol

IL7R

Additional IL-7R alpha/CD127 Products

Product Documents for IL-7R alpha/CD127 Antibody (R34-34)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for IL-7R alpha/CD127 Antibody (R34-34)

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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