IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric - Azide and BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-75193
Recombinant Monoclonal Antibody.
![Immunofluorescence: IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric - Azide and BSA Free [NBP2-75193]](https://resources.bio-techne.com/images/products/IL6R-Antibody-rhPM-1-Tocilizumab-Chimeric-Immunofluorescence-NBP2-75193-img0001.jpg "Immunofluorescence: IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric - Azide and BSA Free [NBP2-75193]")
Conjugate
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human
Applications
Validated:
ELISA, Immunocytochemistry/ Immunofluorescence, Inhibition Activity
Cited:
Immunocytochemistry/ Immunofluorescence
Label
Unconjugated
Antibody Source
Recombinant Monoclonal Rabbit IgG Kappa Clone # rhPM-1 (Tocilizumab)
Format
Azide and BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
The original antibody was generated by CDR grafting of mouse PM-1 antibody onto human REI and NEW framework regions to create rhPM-1.
Specificity
Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG Kappa
Scientific Data Images for IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric - Azide and BSA Free
Immunofluorescence: IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric - Azide and BSA Free [NBP2-75193]
Immunofluorescence: IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric [NBP2-75193] - Immunofluorescence staining of fixed U937 cells with anti-IL-6 receptorantibody rhPM-1 (Tocilizumab). Immunofluorescence analysis of paraformaldehyde fixed U937 cells on coverslips, permeabilized with 0.15% Triton and stained with the chimeric rabbit IgG version of rhPM-1 (Tocilizumab) (NBP2-75193) at 10 ug/ml for 1h followed by Alexa Fluor 488 secondary antibody (1 ug/ml), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom NBP2-75193, DAPI, merged channels and an isotype control. The isotype control was stained with an anti-Fluorescein antibody followed by Alexa Fluor 488 secondary antibody.Applications for IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric - Azide and BSA Free
Application
Recommended Usage
ELISA
1:100 - 1:2000
Application Notes
This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
PBS
Format
Azide and BSA Free
Preservative
0.02% Proclin 300
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
Background: IL6R
Alternate Names
CD126, CD126 antigen, gp80, IL-6 receptor subunit alpha, IL-6R 1, IL-6R subunit alpha, IL-6R-1, IL6RA, IL-6RA, IL-6R-alpha, interleukin 6 receptor, interleukin 6 receptor alpha subunit, interleukin-6 receptor subunit alpha, Membrane glycoprotein 80, MGC104991, biosimilar antibody, biosimilars
Gene Symbol
IL6R
Additional IL6R Products
Product Documents for IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric - Azide and BSA Free
Product Specific Notices for IL6R Antibody (rhPM-1 (Tocilizumab)) - Chimeric - Azide and BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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