Importin beta/KPNB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-94993

Novus Biologicals, part of Bio-Techne
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NB100-94993
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Predicted:

Rat (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunoprecipitation, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all Importin beta/KPNB1 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 826 and 876 of human karyopherin (importin) beta 1 using the numbering given in entry NP_002256.2 (GeneID 3837).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

97 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Importin beta/KPNB1 Antibody

Western Blot: Importin beta/KPNB1 Antibody [NB100-94993]

Western Blot: Importin beta/KPNB1 Antibody [NB100-94993]

Western Blot: Importin beta/KPNB1 Antibody [NB100-94993] - Detection of Human and Mouse KPNB1 on HeLa whole cell lysate using NB100-94993.

Applications for Importin beta/KPNB1 Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Importin beta/KPNB1

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq]

Long Name

Karyopherin beta 1

Alternate Names

IMB1, Impnb, Importin 1, IPOB, KPNB1, NTF97, PTAC97

Entrez Gene IDs

3837 (Human); 16211 (Mouse)

Gene Symbol

KPNB1

UniProt

Q14974 (Human)

Additional Importin beta/KPNB1 Products

Product Documents for Importin beta/KPNB1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Importin beta/KPNB1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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