Inhibin beta A Antibody (CL15357) [Unconjugated]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-43663

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL15357

Concentration

1 mg/ml

View all INHBA Antibodies »

Product Specifications

Immunogen

This antibody was generated using a recombinant protein sequence of P08476, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Inhibin beta A Antibody (CL15357) [Unconjugated]

Inhibin beta A Antibody (CL15357) [Unconjugated] Immunohistochemistry-Paraffin: Inhibin beta A Antibody (CL15357) [NBP3-43663]

Immunohistochemistry-Paraffin: Inhibin beta A Antibody (CL15357) [NBP3-43663]

Analysis in human placenta and kidney tissues using NBP3-43663 antibody. Corresponding INHBA RNA-seq data are presented for the same tissues.
Inhibin beta A Antibody (CL15357) [Unconjugated] Immunohistochemistry-Paraffin: Inhibin beta A Antibody (CL15357) [NBP3-43663]

Immunohistochemistry-Paraffin: Inhibin beta A Antibody (CL15357) [NBP3-43663]

Staining of human prostate shows no positivity in glandular cells as expected.
Inhibin beta A Antibody (CL15357) [Unconjugated] Immunohistochemistry-Paraffin: Inhibin beta A Antibody (CL15357) [NBP3-43663]

Immunohistochemistry-Paraffin: Inhibin beta A Antibody (CL15357) [NBP3-43663]

Staining of rat cerebral cortex shows moderate cytoplasmic positivity in a subset of neurons in the upper layers.
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Applications for Inhibin beta A Antibody (CL15357) [Unconjugated]

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: INHBA

The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.

Long Name

Inhibin Subunit Beta A

Alternate Names

Activin Beta A, Inhibin Beta A, Inhibin Subunit Beta A

Gene Symbol

INHBA

Additional INHBA Products

Product Documents for Inhibin beta A Antibody (CL15357) [Unconjugated]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Inhibin beta A Antibody (CL15357) [Unconjugated]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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