INSL3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-81223

Novus Biologicals, part of Bio-Techne
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NBP1-81223
NBP1-81223-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all INSL3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: EMREKLCGHHFVRALVRVCGGPRWSTEARRPATGGDRELLQWLERRHLLHGLVADSNLTLGPGLQPLPQTSHHHRHHRAAATNPARYCCLSGCTQQDLLTLCPY

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for INSL3 Antibody

Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223]

Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223]

Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223] - Staining in human testis and endometrium tissues using anti-INSL3 antibody. Corresponding INSL3 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223]

Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223]

Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223] - Staining of human testis shows high expression.
Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223]

Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223]

Immunohistochemistry-Paraffin: INSL3 Antibody [NBP1-81223] - Staining of human endometrium shows low expression as expected.

Applications for INSL3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Reported in scientific literature (PMID: 30174296)

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: INSL3

Insulin-like 3 (INSL3), a member of the insulin-like hormone superfamily, is specifically expressed in Leydig cells of the fetal and postnatal testis and in theca cells of the postnatal ovary. It is synthesized as a 131-amino acid preproprotein, which contains a 24-amino acid signal peptide. The human INSL3 gene is assigned to bands p13.2-p12 of the short arm of chromosome 19 with the similar organization to that of insulin and relaxin. INSL3 induces gubernaculum development in an androgen-independent way, while androgen-mediated regression of the CSL occurs independently from Insl3. Moreover, INSL3 is a ligand for LGR8 and INSL3-LGR8 mutations are believed to be associated with human cryptorchidism.

Long Name

Insulin-like 3

Alternate Names

Ley I-L, RLF, RLNL

Entrez Gene IDs

3640 (Human)

Gene Symbol

INSL3

UniProt

P51460

Additional INSL3 Products

Product Documents for INSL3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for INSL3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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