Integrin alpha V beta 5 Antibody (23C6) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-09128

Novus Biologicals, part of Bio-Techne
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NBP3-09128
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Key Product Details

Species Reactivity

Validated:

Human, Chicken

Applications

Flow Cytometry, Immunohistochemistry-Frozen, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 23C6

Format

BSA Free

Concentration

1 mg/ml

View all Integrin alpha V beta 5 Antibodies »

Product Summary for Integrin alpha V beta 5 Antibody (23C6) - BSA Free

Immunogen

A cell suspension containing osteoclasts from osteoclastomas

Reactivity Notes

This antibody does not react with: Rabbit, Porcine, Bovine

Specificity

The mouse monoclonal antibody 23C6 recognizes an extracellular epitope on CD51/CD61 complex, that is expressed mainly on human osteoclasts, but also e.g. on placenta, or melanoma cell lines. The epitope is native and sensitive to fixation. In chicken this antibody can be used to selectively identify the thrombocytes.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Integrin alpha V beta 5 Antibody (23C6) - BSA Free

Flow Cytometry: Integrin alpha V beta 5 Antibody (23C6) - BSA Free [NBP3-09128]

Flow Cytometry: Integrin alpha V beta 5 Antibody (23C6) - BSA Free [NBP3-09128]

Flow Cytometry: Integrin alpha V beta 5 Antibody (23C6) [NBP3-09128] - Separation of MCF-7 cells stained using anti-CD51/CD61 (23c3) purified antibody (concentration in sample 1,7 ug/ml, GAM APC, red-filled) from MCF-7 cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Applications for Integrin alpha V beta 5 Antibody (23C6) - BSA Free

Application
Recommended Usage

Flow Cytometry

2-6 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Integrin alpha V beta 5

Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Alternate Names

CD51, integrin subunit alpha V, ITGAV, MSK8, VNRA, VTNR

Gene Symbol

ITGAV

Additional Integrin alpha V beta 5 Products

Product Documents for Integrin alpha V beta 5 Antibody (23C6) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Integrin alpha V beta 5 Antibody (23C6) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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