Integrin beta 3/CD61 Antibody (CL7319)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-76484

Novus Biologicals, part of Bio-Techne
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NBP2-76484
NBP2-76484-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (92%), Rat (90%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL7319

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Integrin beta 3/CD61 Antibodies »

Product Summary for Integrin beta 3/CD61 Antibody (CL7319)

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGP

Epitope

EKEKSFTIKPVGFKD

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Integrin beta 3/CD61 Antibody (CL7319)

Integrin beta 3/CD61 Antibody (CL7319)

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody (CL7319) [NBP2-76484] -

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody (CL7319) [NBP2-76484] - Analysis in human thyroid gland and pancreas tissues using NBP2-76484 antibody. Corresponding ITGB3 RNA-seq data are presented for the same tissues.
Western Blot: Integrin beta 3/CD61 Antibody (CL7319) [NBP2-76484]

Western Blot: Integrin beta 3/CD61 Antibody (CL7319) [NBP2-76484]

Western Blot: Integrin beta 3/CD61 Antibody (CL7319) [NBP2-76484] - Analysis in human cell line EFO-21.
Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody (CL7319) [NBP2-76484]

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody (CL7319) [NBP2-76484]

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody (CL7319) [NBP2-76484] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
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Applications for Integrin beta 3/CD61 Antibody (CL7319)

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, containing 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Integrin beta 3/CD61

Platelet membrane glycoprotein Integrin beta-3 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. A biochemically and immunologically similar membrane glycoprotein complex is present on endothelial cells. Homology suggests that GP IIIa is a member of a family of cell-surface adhesion receptors. (1) Data provide further support for the key role of the cytoplasmic domain of the beta3 integrin in cell adhesion and suggest a potential role for the beta3C integrin subunit in modulating cell-matrix interactions (2). It has been demonstrated that the beta 3 subunit of alpha IIb beta 3 was phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3). be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3).

Alternate Names

CD61, GP3A, GPIIIA, INGRB3, ITGB3

Gene Symbol

ITGB3

Additional Integrin beta 3/CD61 Products

Product Documents for Integrin beta 3/CD61 Antibody (CL7319)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Integrin beta 3/CD61 Antibody (CL7319)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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