Integrin beta 4/CD104 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38297

Novus Biologicals, part of Bio-Techne
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NBP2-38297
NBP2-38297-25ul
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human, Rat

Cited:

Mouse, Rat

Predicted:

Mouse (97%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Integrin beta 4/CD104 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: MKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRS

Reactivity Notes

Use in Rat reported in scientific literature (PMID:34971784) .

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Integrin beta 4/CD104 Antibody

Immunocytochemistry/ Immunofluorescence: Integrin beta 4/CD104 Antibody [NBP2-38297]

Immunocytochemistry/ Immunofluorescence: Integrin beta 4/CD104 Antibody [NBP2-38297]

Immunocytochemistry/Immunofluorescence: Integrin beta 4/CD104 Antibody [NBP2-38297] - Staining of human cell line HaCaT shows localization to nucleus, plasma membrane & cell junctions. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Integrin beta 4/CD104 Antibody [NBP2-38297]

Immunohistochemistry-Paraffin: Integrin beta 4/CD104 Antibody [NBP2-38297]

Immunohistochemistry-Paraffin: Integrin beta 4/CD104 Antibody [NBP2-38297] - Staining of human duodenum shows moderate to strong membranous positivity in glandular cells.
Immunohistochemistry-Paraffin: Integrin beta 4/CD104 Antibody [NBP2-38297]

Immunohistochemistry-Paraffin: Integrin beta 4/CD104 Antibody [NBP2-38297]

Immunohistochemistry-Paraffin: Integrin beta 4/CD104 Antibody [NBP2-38297] - Staining of human skin shows moderate to strong membranous positivity in keratinocytes.
View 3 more images

Applications for Integrin beta 4/CD104 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Integrin beta 4/CD104

Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.

Alternate Names

CD104, ITGB4

Gene Symbol

ITGB4

UniProt

P16144

Additional Integrin beta 4/CD104 Products

Product Documents for Integrin beta 4/CD104 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Integrin beta 4/CD104 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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