Intersectin 1 Antibody (2F12)

Novus Biologicals, part of Bio-Techne | Catalog # H00006453-M02-100ug

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 2F12

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Intersectin 1 Antibodies »

Product Specifications

Immunogen

ITSN1 (NP_003015.2, 588 a.a. ~ 675 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. EVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRK

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for Intersectin 1 Antibody (2F12)

Western Blot: Intersectin 1 Antibody (2F12) [H00006453-M02-100ug]

Western Blot: Intersectin 1 Antibody (2F12) [H00006453-M02-100ug]

Western Blot: Intersectin 1 Antibody (2F12) [H00006453-M02-100ug] - Detection against Immunogen (35.42 KDa) .
ELISA: Intersectin 1 Antibody (2F12) [H00006453-M02-100ug]

ELISA: Intersectin 1 Antibody (2F12) [H00006453-M02-100ug]

ELISA: Intersectin 1 Antibody (2F12) [H00006453-M02-100ug] - Detection limit for recombinant GST tagged ITSN1 is 0.03 ng/ml as a capture antibody.

Applications for Intersectin 1 Antibody (2F12)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Intersectin 1

Intersectin 1 is an adapter protein that may provide an indirect link between the endocytic membrane traffic and the actin assembly machinery. It may regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Intersectin 1 is overexpressed in brain from Down syndrome foetuses suggesting a gene dosage-dependent contribution to the abnormalities of Down syndrome. Intersectin 1 interacts with dynamin, CDC42, SNAP25 and SNAP23. It clusters several dynamin in a manner that is regulated by alternative splicing. Intersectin 1 also binds clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2 and STN2. Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling.

Alternate Names

11, intersectin 1 (SH3 domain protein), intersectin short variant 12, intersectin-1, ITSN, SH3 domain protein-1A, SH3 domain-containing protein 1A, Src homology 3 domain-containing protein

Entrez Gene IDs

6453 (Human)

Gene Symbol

ITSN1

OMIM

602442 (Human)

UniProt

NP_003015.2 (Human)

Additional Intersectin 1 Products

Product Documents for Intersectin 1 Antibody (2F12)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Intersectin 1 Antibody (2F12)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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