Intersectin 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-41833

Novus Biologicals, part of Bio-Techne
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NBP3-41833
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Key Product Details

Species Reactivity

Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all Intersectin 1 Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Rat Intersectin 1 (Uniprot#: Q9WVE9; Met1-Gln227 (Uniprot#: Q9WVE9)

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for Intersectin 1 Antibody

Intersectin 1 Antibody

Western Blot: Intersectin 1 Antibody [NBP3-41833] -

Western Blot: Intersectin 1 Antibody [NBP3-41833] - Sample: Recombinant protein.
Intersectin 1 Antibody

Immunohistochemistry-Paraffin: Intersectin 1 Antibody [NBP3-41833] -

Immunohistochemistry-Paraffin: Intersectin 1 Antibody [NBP3-41833] - DAB staining on IHC-P; Samples: Rat Kidney Tissue; Primary Ab: 10ug/ml NBP3-41833; Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Intersectin 1 Antibody

Western Blot: Intersectin 1 Antibody [NBP3-41833] -

Western Blot: Intersectin 1 Antibody [NBP3-41833] - Sample: Mouse Gallbladder lysate; Primary Ab: 1ug/ml NBP3-41833; Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody

Applications for Intersectin 1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

5-20ug/mL

Immunohistochemistry

5-20ug/mL

Western Blot

0.01-2ug/mL

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

PBS, pH7.4, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Intersectin 1

Intersectin 1 is an adapter protein that may provide an indirect link between the endocytic membrane traffic and the actin assembly machinery. It may regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Intersectin 1 is overexpressed in brain from Down syndrome foetuses suggesting a gene dosage-dependent contribution to the abnormalities of Down syndrome. Intersectin 1 interacts with dynamin, CDC42, SNAP25 and SNAP23. It clusters several dynamin in a manner that is regulated by alternative splicing. Intersectin 1 also binds clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2 and STN2. Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling.

Alternate Names

11, intersectin 1 (SH3 domain protein), intersectin short variant 12, intersectin-1, ITSN, SH3 domain protein-1A, SH3 domain-containing protein 1A, Src homology 3 domain-containing protein

Gene Symbol

ITSN1

Additional Intersectin 1 Products

Product Documents for Intersectin 1 Antibody

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Certificate of Analysis

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Product Specific Notices for Intersectin 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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