IQCB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-14126

Novus Biologicals, part of Bio-Techne
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NBP2-14126
NBP2-14126-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all IQCB1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the amino acids: AVTLQRAALKFLAKCRKKKKLFAPWRGLQELTDARRVELKKRVDDYVRRHLGSPMSDVVSRELHAQAQERLQHYFMGRALEERAQQHREALIAQISTNVEQLMK

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (86%), Rat (88%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IQCB1 Antibody

Immunocytochemistry/ Immunofluorescence: IQCB1 Antibody [NBP2-14126]

Immunocytochemistry/ Immunofluorescence: IQCB1 Antibody [NBP2-14126]

Immunocytochemistry/Immunofluorescence: IQCB1 Antibody [NBP2-14126] - Staining of human cell line U-2 OS shows localization to nucleoplasm, microtubules, cytokinetic bridge & mitotic spindle.
Immunohistochemistry-Paraffin: IQCB1 Antibody [NBP2-14126]

Immunohistochemistry-Paraffin: IQCB1 Antibody [NBP2-14126]

Immunohistochemistry-Paraffin: IQCB1 Antibody [NBP2-14126] - Staining of human retina shows strong cytoplasmic positivity in cones.

Applications for IQCB1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF,Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IQCB1

CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. CEP290 is ubiquitously expressed; strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) , Senior-Loken syndrome type 6 (SLSN6) , Leber congenital amaurosis type 10 (LCA10) and Meckel syndrome type 4 (MKS4) . Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.

Alternate Names

IQ calmodulin-binding motif containing 1, IQ motif containing B1, KIAA0036nephrocystin 5, Nephrocystin-5, NPHP5IQ calmodulin-binding motif-containing protein 1, p53 and DNA damage-regulated IQ motif protein, PIQ, SLSN5

Gene Symbol

IQCB1

Additional IQCB1 Products

Product Documents for IQCB1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for IQCB1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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