IRS1 [p Tyr1179] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-74450

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NB100-74450
NB100-74450-0.025mg
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all IRS1 Antibodies »

Product Summary for IRS1 [p Tyr1179] Antibody

Immunogen

Synthetic phosphopeptide corresponding to residues L(1173) E N G L N (pY) I D L D L V K(1186) of human IRS-1.

Modification

p Tyr1179

Localization

Cytoplasmic

Specificity

Detects phosphorylated IRS-1 (Tyr1173) in mouse cells.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IRS1 [p Tyr1179] Antibody

Western Blot: IRS1 [p Tyr1179] Antibody [NB100-74450]

Western Blot: IRS1 [p Tyr1179] Antibody [NB100-74450]

Western Blot: IRS1 [p Tyr1179] Antibody [NB100-74450] - Lysate from insulin-treated 3T3 L1 cells.

Applications for IRS1 [p Tyr1179] Antibody

Application
Recommended Usage

Western Blot

1:100 - 1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IRS1

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS-1, 2, 3 and 4, with IRS-1 being widely expressed.

Long Name

Insulin Receptor Substrate 1

Alternate Names

HIRS-1, insulin receptor substrate 1, IRS-1

Entrez Gene IDs

16367 (Mouse)

Gene Symbol

IRS1

Additional IRS1 Products

Product Documents for IRS1 [p Tyr1179] Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for IRS1 [p Tyr1179] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.