ITCH/AIP4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-18881

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP1-18881
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

Immunoprecipitation (Negative), Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all ITCH/AIP4 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 650 to 700 of human itchy homolog E3 ubiquitin protein ligase using the numbering given in entry AAH11571.1 (GeneID 83737).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ITCH/AIP4 Antibody

Western Blot: ITCH/AIP4 Antibody [NBP1-18881]

Western Blot: ITCH/AIP4 Antibody [NBP1-18881]

Western Blot: ITCH/AIP4 Antibody [NBP1-18881] - Whole cell lysate (5, 15 and 50 ug) from Jurkat cells. Antibody used at 0.04 ug/ml.

Applications for ITCH/AIP4 Antibody

Application
Recommended Usage

Western Blot

1:100-1:2000
Application Notes
This antibody is useful for western blot. It is not recommended for immunoprecipitation.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: ITCH/AIP4

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq]

Long Name

Itchy E3 Ubiquitin Protein Ligase

Alternate Names

AIF4, AIP4, NAPP1

Entrez Gene IDs

83737 (Human)

Gene Symbol

ITCH

UniProt

AAH11571.1 (Human)

Additional ITCH/AIP4 Products

Product Documents for ITCH/AIP4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ITCH/AIP4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.